5(6)-Carboxynaphthofluorescein
| Code | Size | Price |
|---|
| CDX-C0047-M025 | 25 mg | £92.00 |
Quantity:
| CDX-C0047-M100 | 100 mg | £254.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term: +20°C. Long term: +20°C
Documents
Further Information
Alternate Names/Synonyms:
CNF
Appearance:
Deep blue to deep violet powder.
CAS:
128724-35-6
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChi=1S/2C29H16O7/c30-17-4-6-19-14(11-17)1-9-23-25(19)35-26-20-7-5-18(31)12-15(20)2-10-24(26)29(23)22-8-3-16(27(32)33)13-21(22)28(34)36-29;30-17-4-7-19-14(11-17)2-9-22-25(19)35-26-20-8-5-18(31)12-15(20)3-10-23(26)29(22)24-13-16(27(32)33)1-6-21(24)28(34)36-29/h2*1-13,30-31H,(H,32,33)
InChiKey:
ANUHNEJUELPITC-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 128724-35-6. Formula: C29H16O7. MW: 476.43. 5(6)-Carboxynaphthofluorescein (CNF) is a fluorescent NIR emitting pH indicator with red fluorescence at pH 9 (Spectral: Ex/Em: 598/668 nm). The fluorescence shifs to shorter wavelengths (Ex/Em: 512/567nm) at neutral or acidic pH environments. Spectral data: lambdaex=512nm; lambdaem=567nm (acid/neutral); lambdaex=598nm; lambdaem=668nm (basic). CNF shows good sensitivity in an alkaline pH range and it can be exploited in the construction of fiber-optic pH sensors. CNF has been used as an intravesicular pH probe for the colorimetric detection of activity, selectivity and cooperativity of ion channels. CNF has been used to design a luminescent probe for determination of pH, based on a Forster resonance energy transfer (FRET) system, combining a europium chelate as the donor and CNF as a pH sensitive acceptor. The FRET system enables referenced pH detection in an exceptional broad dynamic range from pH 3 to 9.
MDL:
MFCD01862976
Molecular Formula:
C29H16O7
Molecular Weight:
476.43
Package Type:
Vial
Product Description:
5(6)-Carboxynaphthofluorescein (CNF) is a fluorescent NIR emitting pH indicator with red fluorescence at pH 9 (Spectral: Ex/Em: 598/668 nm). The fluorescence shifs to shorter wavelengths (Ex/Em: 512/567nm) at neutral or acidic pH environments. Spectral data: lambdaex=512nm; lambdaem=567nm (acid/neutral); lambdaex=598nm; lambdaem=668nm (basic). CNF shows good sensitivity in an alkaline pH range and it can be exploited in the construction of fiber-optic pH sensors. CNF has been used as an intravesicular pH probe for the colorimetric detection of activity, selectivity and cooperativity of ion channels. CNF has been used to design a luminescent probe for determination of pH, based on a Forster resonance energy transfer (FRET) system, combining a europium chelate as the donor and CNF as a pH sensitive acceptor. The FRET system enables referenced pH detection in an exceptional broad dynamic range from pH 3 to 9.
Purity:
>90% (HPLC)
SMILES:
OC(=O)c1ccc2c(c1)C(=O)OC23c4ccc5cc(O)ccc5c4Oc6c3ccc7cc(O)ccc67.OC(=O)c8ccc9C(=O)OC%10(c%11ccc%12cc(O)ccc%12c%11Oc%13c%10ccc%14cc(O)ccc%13%14)c9c8
Solubility Chemicals:
Soluble in DMSO or methanol (5mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) A. Song, et al.; Anal. Chem. 69, 863 (1997) | (2) S.M. Butterfield, et al.; Org. Biomol. Chem. 7, 1784 (2009) | (3) R.J. Meier, et al.; Chem. Commun. 51, 6145 (2015) | (4) E. Poehler, et al. Anal. Bioanal. Chem. 408, 2927 (2016) | (5) D.A. Jankowska, et al.; Biosens. Bioelectr. 87, 312 (2017) | (6) S. Nevolova, et al.; Biotech. J. 14, 1800144 (2019)