anti-ST2 (human) pAb

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AdipoGen Life Sciences
Product Code: AG-25A-0058
Product Group: Primary Antibodies
CodeSizePrice
AG-25A-0058-C100100 ug£249.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C

Images

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Detection of endogenous human ST2 with anti-ST2 (human), pAb (AG-25A-0058). Method: THP1 cells were stained with anti-ST2 (human), pAb (1:100 in PBS + 2% FCS) (Figure B) or with the secondary antibody alone (Figure A) for 1h at 4?C. The staining wa
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Detection of endogenous human ST2 with anti-ST2 (human), pAb (AG-25A-0058). Method: THP1 cells were stained with anti-ST2 (human), pAb (1:100 in PBS + 2% FCS) (Figure B) or with the secondary antibody alone (Figure A) for 1h at 4?C. The staining wa

Documents

Further Information

Alternate Names/Synonyms:
Interleukin-1 Receptor-like 1; IL-1 Receptor-like 1; IL1RL1; Interleukin-33 Receptor; IL-33-Receptor
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human soluble ST2.
Long Description:
Polyclonal Antibody. Recognizes soluble human ST2. Detects a band of ~50kDa by Western blot and the endogenous ST2 by Flow Cytometry. Source: Rabbit. Applications: ELISA, FACS, WB. Liquid. In PBS containing 0.02% sodium azide. ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a na?ve state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
NCBI, Uniprot Number:
Q01638
Package Type:
Plastic Vial
Product Description:
ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a na?ve state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
Source / Host:
Rabbit
Specificity:
Recognizes soluble human ST2. Detects a band of ~50kDa by Western blot and the endogenous ST2 by Flow Cytometry.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.