OX40 (human):Fc (human) (rec.) (MultiPack)
| Code | Size | Price |
|---|
| AG-40B-0014-C050 | 50 ug | £165.00 |
Quantity:
| AG-40B-0014-3050 | 3 x 50 ug | £320.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Shipping:
Blue Ice
Storage:
-20°C
Further Information
Alternate Names/Synonyms:
TNFRSF 4; Tumor Necrosis Factor Receptor Superfamily Member 4; CD134
Biological Activity:
Blocks T cell proliferation induced by CD134L.
Concentration:
1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse OX40L. Purity: >95% (SDS-PAGE). OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
Molecular Weight:
~70kDa (SDS-PAGE)
NCBI, Uniprot Number:
P43489
Package Type:
Plastic Vial
Product Description:
OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
Purity:
>95% (SDS-PAGE)
Sequence:
Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
Specificity:
Binds to human and mouse OX40L.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.