TNF-R1 (human):Fc (human) (rec.) (MultiPack)
| Code | Size | Price |
|---|
| AG-40B-0074-C050 | 50 ug | £165.00 |
Quantity:
| AG-40B-0074-3050 | 3 x 50 ug | £320.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
p55; CD120a; TNFRSF 1A; Tumor Necrosis Factor Receptor Superfamily Member 1A; TNF Receptor 1
Biological Activity:
TNF-R1:Fc fusion protein blocks TNF-alpha-mediated biological effect with an inhibitory activity in a concentration range of 0.1 to 1µg/ml.
Concentration:
1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds human and mouse TNF-alpha. Purity: >95% (SDS-PAGE). TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Molecular Weight:
~60kDa (reducing SDS-PAGE)
NCBI, Uniprot Number:
P19438
Package Type:
Plastic Vial
Product Description:
TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Purity:
>95% (SDS-PAGE)
Sequence:
The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
Specificity:
Binds human and mouse TNF-alpha.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Differences in the sensitivity of classically and alternatively activated macrophages to TAK1 inhibitor?induced necroptosis: Z. Varga, et al.; Cancer Immunol. Immunother. 69, 2193 (2020) | Cytotoxic activity of human dendritic cells induces RIPK1-dependent cell death: Z. Varga, et al.; Immunobiol. 226, 152032 (2021)