TRAIL-R1 to -R4 Flow Cytometry Pack

32160000

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

100µg each of: anti-TRAIL-R1 (clone HS101, Prod. No. AG-20B-0022 | anti-TRAIL-R2 (clone HS201, Prod. No. AG-20B-0023) | anti-TRAIL-R3 (clone HS301, Prod. No. AG-20B-0024) | anti-TRAIL-R4 (clone HS402, Prod. No. AG-20B-0025)

Set. TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Plastic Vial

TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Non-hazardous

General Purpose Cell Biology Kits

41116111

Stable for at least 6 months after receipt when stored at -20°C.