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1,5-Isoquinolinediol

Product Code:
 
AG-CR1-0024
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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AG-CR1-0024-M0055 mg£35.00
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AG-CR1-0024-M02525 mg£65.00
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AG-CR1-0024-M100100 mg£175.00
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Further Information

Alternate Names/Synonyms:
5-Hydroxy-1(2H)-isoquinolinone; 1,5-Dihydroxyisoquinoline
Appearance:
White to off-white solid.
CAS:
09/02/5154
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChiKey:
LFUJIPVWTMGYDG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 5154-02-9. Formula: C9H7NO2. MW: 161.2. PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination.
MDL:
MFCD00006900
Molecular Formula:
C9H7NO2
Molecular Weight:
161.2
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
PARP-1 inhibitor [1]. Neuroprotectant [2]. Blocks nitric oxide-induced neuronal toxicity [2]. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor [3]. Stimulates homologous recombination [4].
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
OC1=CC=CC2=C(O)N=CC=C12
Solubility Chemicals:
Soluble in DMSO (20mg/ml), DMF (20mg/ml), ethanol (10mg/ml) or methanol (5mg/ml). Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) | Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) | Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006) | 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003)