Ciglitazone
| Code | Size | Price |
|---|
| AG-CR1-0033-M001 | 1 mg | £40.00 |
Quantity:
| AG-CR1-0033-M005 | 5 mg | £80.00 |
Quantity:
| AG-CR1-0033-M025 | 25 mg | £290.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
+4°C
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
(?)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione; U-63287
Appearance:
Off-white solid.
CAS:
74772-77-3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H302, H312
InChi:
InChI=1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
InChiKey:
YZFWTZACSRHJQD-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 74772-77-3. Formula: C18H23NO3S. MW: 333.5. Selective PPARgamma agonist (EC50=3 µM). Hypoglycemic agent. Angiogenesis inhibitor. Anti-inflammatory. Apoptosis inducer.
MDL:
MFCD00865499
Molecular Formula:
C18H23NO3S
Molecular Weight:
333.5
Other data:
Stock solutions are stable for up to 3 months when stored at -20°C.
Package Type:
Vial
Precautions:
P264, P270, P280, P301, P312
Product Description:
Selective PPARgamma agonist (EC50=3 µM) [1]. Hypoglycemic agent [2, 3]. Angiogenesis inhibitor [4]. Anti-inflammatory [5]. Apoptosis inducer [6].
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1
Solubility Chemicals:
Soluble in DMSO or 100% ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996) | Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent: T. Fujita, et al.; Diabetes 32, 804 (1983) | [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994) | Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999) | The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice: M.E. Stegenga, et al.; Crit. Care Med. 37, 614 (2009) | Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock: R.S. Chima, et al.; Int. J. Clin. Exp. Med. 3, 1 (2010)
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