Dynasore
| Code | Size | Price |
|---|
| AG-CR1-0045-M005 | 5 mg | £45.00 |
Quantity:
| AG-CR1-0045-M025 | 25 mg | £160.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzyl-idene)-hydrazide . 0.5H2O
Appearance:
Off-white solid.
CAS:
304448-55-3 (free base) 1202867-00-2 (x H2O)
Class:
9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS09
Handling Advice:
Protect from light.
Hazards:
H400
InChi:
InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChiKey:
SYNDQCRDGGCQRZ-VXLYETTFSA-N
Long Description:
Chemical. CAS: 304448-55-3 (free base) 1202867-00-2 (x H2O). Formula: C18H14N2O4 . 0.5H2O. MW: 322.3 . 9.0. Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor. Endocytosis inhibitor. Viral infection inhibitor. Destabilizes actin filaments. Inhibits entry of Trypanosoma into macrophages. Inhibitor of mitophagy. Inhibitor of hepatocyte lipophagy
MDL:
MFCD11045288
Molecular Formula:
C18H14N2O4 . 0.5H2O
Molecular Weight:
322.3 . 9.0
Other data:
Stock solutions are stable for up to 3 months when stored at -20°C.
Package Type:
Vial
PG:
III
Precautions:
P273, P391
Product Description:
Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor [1]. Endocytosis inhibitor [1, 2]. Viral infection inhibitor [3]. Destabilizes actin filaments [4]. Inhibits entry of Trypanosoma into macrophages [5]. Inhibitor of mitophagy. Inhibitor of hepatocyte lipophagy
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
OC1=CC2=C(C=CC=C2)C=C1C(=O)NN=CC1=CC(O)=C(O)C=C1
Solubility Chemicals:
Soluble in 100% ethanol (1 mg/ml) or DMSO (10 mg/ml); insoluble in water.
Transportation:
Excepted Quantity
UN Nummer:
UN 3077
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Dynasore, a cell-permeable inhibitor of dynamin.: E. Macia, et al. ; Dev. Cell. 10, 839 (2006) | Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis: T. Kirchhausen, et al.; Meth. Enzymol. 438, 77 (2008) | HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore: C.Y. Abban, et al.; Am. J. Ther. 15, 304 (2008) | Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments: H. Yamada, et al.; BBRC 390, 1142 (2009) | Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages: E.S. Barrias, et al.; PLoS One 5, e7764 (2010) | Mitochondrial dynamics and mitophagy in the 6-hydroxydopamine preclinical model of Parkinson's disease: M.F. Galindo, et al.; Parkinsons Dis. 131058 (2012) | A well-oiled machine: DNM2/dynamin 2 helps keep hepatocyte lipophagy running smoothly: RJ. Schulze & MA. McNiven; Autophagy 10, 388 (2013) | Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT: R. Padmanabhan & L.A. Taneyhill; J. Cell Sci. 128, 1773 (2015) | Monoclonal anti-dsDNA antibody 2C10 escorts DNA to intracellular DNA sensors in normal mononuclear cells and stimulates secretion of multiple cytokines implicated in lupus pathogenesis: K. Inoue, et al.; Clin. Exper. Immunol. ahead of print (2019) | Enhanced lysosomal degradation maintains the quiescent state of neural stem cells: T. Kobayashi, et al.; Nat. Comm. in press, (2019)