Chrysomycin A
| Code | Size | Price |
|---|
| BVT-0099-C250 | 250 ug | £160.00 |
Quantity:
| BVT-0099-M001 | 1 mg | £385.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Chrysomycin V; Virenomycin V
Appearance:
Yellow to greenish solid.
CAS:
82196-88-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS08
Handling Advice:
Protect from light.
Hazards:
H302, H312, H319, H351
InChi:
InChI=1S/C28H28O9/c1-6-13-9-16-20(18(10-13)34-4)15-11-19(35-5)22-17(29)8-7-14(21(22)23(15)37-27(16)32)24-26(31)28(3,33)25(30)12(2)36-24/h6-12,24-26,29-31,33H,1H2,2-5H3/t12-,24+,25+,26+,28-/m1/s1
InChiKey:
OMDANBMKOUVKAG-WZNMFJNZSA-N
Long Description:
Chemical. CAS: 82196-88-1. Formula: C28H28O9. MW: 508.5. Isolated from Streptomyces sp. Antibiotic. Topoisomerase II inhibitor. Mediates a unique cross-linking reaction between DNA and histidine H3. Anti-neoplastic. Photosensitizing compound. Antitumor compound against human cell lines.
MDL:
MFCD07370133
Molecular Formula:
C28H28O9
Molecular Weight:
508.5
Package Type:
Plastic Vial
Precautions:
P201, P270, P281, P301, P312, P302, P352, P405
Product Description:
Antibiotic. Topoisomerase II inhibitor. Mediates a unique cross-linking reaction between DNA and histidine H3. Anti-neoplastic. Photosensitizing compound. Antitumor compound against human cell lines.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
COC1=CC2=C(OC(=O)C3=CC(C=C)=CC(OC)=C23)C2=C1C(O)=CC=C2[C@@H]1OC(C)[C@H](O)[C@](C)(O)C1O
Solubility Chemicals:
Soluble in DMSO or dimethylformamide; slightly soluble in 100% ethanol or methanol.
Source / Host:
Isolated from Streptomyces sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
References
Chrysomycin: a new antibiotic substance for bacterial viruses: F. Strelitz, et al.; J. Bacteriol. 69, 280 (1955) | The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A: U. Weiss, et al.; J. Antibiot. 35, 1194 (1982) | Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B.H. Long; Eur. J. Cancer 29A, 1985 (1993) | Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and B: S. Wada, et al.; J. Antibiot. 70, 1078 (2017) | Anti-microbial activity of chrysomycin A produced by Streptomyces sp. against Mycobacterium tuberculosis: B. Muralikrishnan, et al.; RSC Adv. 7, 36335 (2017)
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