Saquayamycin B1
| Code | Size | Price |
|---|
| BVT-0382-C500 | 500 ug | £110.00 |
Quantity:
| BVT-0382-M001 | 1 mg | £170.00 |
Quantity:
| BVT-0382-M005 | 5 mg | £490.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Appearance:
Orange powder.
CAS:
99260-68-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS08
Hazards:
H302, H319, H350
InChi:
InChI=1S/C31H32O12/c1-12-17(32)8-20-28(41-12)43-27-13(2)40-18(9-19(27)42-20)14-4-5-15-22(24(14)34)25(35)16-6-7-30(38)11-29(3,37)10-21(33)31(30,39)23(16)26(15)36/h4-7,12-13,18-20,27-28,34,37-39H,8-11H2,1-3H3/t12?,13-,18-,19-,20?,27-,28+,29+,30+,31+/m1/s1
InChiKey:
CTSPXNCFVRSKKD-IGVHUSDSSA-N
Long Description:
Chemical. CAS: 99260-68-1. Formula: C31H32O12. MW: 596.6. Isolated from Streptomyces nodosus. Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1).
Molecular Formula:
C31H32O12
Molecular Weight:
596.6
Package Type:
Plastic Vial
Precautions:
P201, P280, P301, P312, P305, P351, 338, P337, P313, P405
Product Description:
Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1).
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
CC1OC(CC2OC3CC(=O)C(C)OC3OC12)C1=CC=C2C(=O)C3=C(C=C[C@]4(O)C[C@@](C)(O)CC(=O)[C@]34O)C(=O)C2=C1O
Solubility Chemicals:
Soluble in DMSO, methanol or chloroform.
Source / Host:
Isolated from Streptomyces nodosus.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Saquayamycins, new aquayamycin-group antibiotics: T. Uchida, et al.; J. Antibiot. 38, 1171 (1985) | Angucycline group antibiotics: J. Rohr & R. Thiericke; Nat. Prod. Rep. 9, 103 (1992) (Review) | Isolation of novel saquayamycins as inhibitors of farnesyl-protein transferase: R. Sekizawa, et al.; J. Antibiot. 49, 487(1996) | Identification of inhibitors of inducible nitric oxide synthase from microbial extracts: A. A. Khisal, et al.; J. Antibiot. 53, 496 (2000) | Moromycins A and B: M. S. Abdelfattah, et al.; J. Nat. Prod. 71, 1569 (2008)
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