Kaempferitrin
Product Code: AG-CN2-0039
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0039-M001 | 1 mg | £55.00 |
Quantity:
| AG-CN2-0039-M005 | 5 mg | £160.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Documents
Further Information
Alternate Names/Synonyms:
Lespenefril; Lespedin; BRN 0073958; Kaempferol 3,7-dirhamnoside
Appearance:
Yellow solid.
CAS:
482-38-2
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Protect from light.
Hazards:
H302, H319
InChi:
InChI=1S/C27H30O14/c1-9-17(30)20(33)22(35)26(37-9)39-13-7-14(29)16-15(8-13)40-24(11-3-5-12(28)6-4-11)25(19(16)32)41-27-23(36)21(34)18(31)10(2)38-27/h3-10,17-18,20-23,26-31,33-36H,1-2H3/t9-,10-,17-,18-,20+,21+,22+,23+,26-,27-/m0/s1
InChiKey:
PUPKKEQDLNREIM-QNSQPKOQSA-N
Long Description:
Chemical. CAS: 482-38-2. Formula: C27H30O14. MW: 578.5. Isolated from Cinnamomum sp. Cytotoxic and anti-inflammatory compound (weak). Antioxidant. Lipid peroxidation inhibitor. Free radical scavenger. Inhibitor of myeloperoxidase activity. Hypoglycemic. Decreases blood glucose levels in diabetic and normal rats. Insulinomimetic. Modulates glucose homeostasis. Decreases blood glucose levels and stimulates glucose uptake in muscle. Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells. Improves insulin resistance by the activation of the classical insulin transduction pathway. Increases adiponectin secretion in 3T3-L1 adipocytes. Antinoniceptive. May have antidyslipidemic activity.
MDL:
MFCD21333499
Molecular Formula:
C27H30O14
Molecular Weight:
578.5
Package Type:
Vial
Precautions:
P301, P312, P305, P351, P338
Product Description:
Cytotoxic and anti-inflammatory compound (weak) [1, 4, 8, 10, 11]. Antioxidant [2, 5]. Lipid peroxidation inhibitor [2, 5]. Free radical scavenger [2, 5]. Inhibitor of myeloperoxidase activity [2, 5]. Hypoglycemic. Decreases blood glucose levels in diabetic and normal rats [2, 3]. Insulinomimetic. Modulates glucose homeostasis [12]. Decreases blood glucose levels and stimulates glucose uptake in muscle [3]. Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells [6]. Improves insulin resistance by the activation of the classical insulin transduction pathway [7]. Increases adiponectin secretion in 3T3-L1 adipocytes [7]. Antinoniceptive [8]. May have antidyslipidemic activity [9].
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
O=C1C2=C(O)C=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C=C2OC(C4=CC=C(O)C=C4)=C1O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O
Solubility Chemicals:
Soluble in ethanol or DMSO.
Source / Host:
Isolated from Calendula officinalis.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Kaempferitrin from the leaves of Hedyotis verticillata and its biological activity: A.S. Hamzah, et al.; Planta Med. 60, 388 (1994) | Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves: E. de Sousa, et al.; J. Nat. Prod. 67, 829 (2004) | Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle: A.P. Jorge, et al.; Chem. Biol. Interact. 149, 89 (2004) | Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-gamma-activated murine macrophages: S.H. Fang, et al.; Bioorg. Med. Chem. 13, 2381 (2005) | Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors: L.O. Regasini, et al.; Phytochemistry 69, 1739 (2008) | Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes: C.N. Vishnu Prasad, et al.; BBRC 380, 39 (2009) | Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes: Y.M. Tzeng, et al.; Eur. J. Pharmacol. 607, 27 (2009) | Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum: G.O. De Melo, et al.; J. Ethnopharmacol. 124, 228 (2009) | Antidyslipidemic Activity of Hot-water Extracts from Leaves of Cinnamomum osmophloeum Kaneh: T.Y. Lin, et al.; Phytother. Res. 25, 1317 (2011) | Lotus corniculatus regulates the inflammation induced by bradykinin in a murine model of pleurisy: D.A. Pereira, et al.; J. Agric. Food Chem. 59, 2291 (2011) | Kaempferol and kaempferol rhamnosides with depigmenting and anti-inflammatory properties: H.S. Rho, et al.; Molecules 16, 3338 (2011) | Effects of flavonoids on alpha-glucosidase activity: potential targets for glucose homeostasis: D.F. Pereira, et al.; Nutrition 27, 1161 (2011)
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