IL-10 (mouse):Fc (mouse) (rec.) (non-lytic)
| Code | Size | Price |
|---|
| CHI-MF-12010-C010 | 10 ug | £275.00 |
Quantity:
| CHI-MF-12010-C050 | 50 ug | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Shipping:
BI
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Interleukin-10; Cytokine Sythesis Inhibitory Factor; CSIF
Biological Activity:
Shows the biological function of the IL-10 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
EClass:
32160000
Endotoxin:
<0.06EU/µg protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. The extracellular domain of mouse IL-10 (aa 1-178) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >98% (SDS-PAGE). Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
NCBI, Uniprot Number:
AAI37845.1
Package Type:
Plastic Vial
Product Description:
Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
Purity:
>98% (SDS-PAGE)
Sequence:
The extracellular domain of mouse IL-10 (aa 1-178) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.
Source / Host:
CHO cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Interleukins
UNSPSC Number:
41116127
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation: X.X. Zheng, et al.; J. Immunol. 154, 5590 (1995) | Recombinant IL-10 and IL-10/Fc treatment down-regulate egg antigen- specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis: P.O. Flores-Villanueva, et al.; J. Immunol. 156, 3315 (1996) | A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice: X.X. Zheng, et al.; J. Immunol. 158, 4507 (1997) | IL-10/Fc inhibits macrophage function and prolongs pancreatic islet xenograft survival: X. Feng, et al.; Transplantation 68, 1775 (1999) | Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis: K. Emmanuilidis, et al.; J. Immunol. 167, 3919 (2001)
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