Angiopoietin-2 (human) (rec.)

AdipoGen Life Sciences
Product Code: AG-40B-0114
Product Group: Recombinant Proteins

CodeSizePrice
AG-40B-0114-C01010 ug£180.00
Quantity:
AG-40B-0114-30103 x 10 ug£350.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Antibody Clonality: Enzyme
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Shipping:
Blue Ice
Storage:
-20°C

Images

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Further Information

Alternate Names/Synonyms:
Ang-2; Ang2; Angpt2
Concentration:
0.1 mg /ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS with trehalose and Brij35.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS with trehalose and Brij35. Binds to the human and mouse Tie-2 receptor. Purity: >95% (SDS-PAGE). Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
Molecular Weight:
~70kDa (SDS-PAGE)
NCBI, Uniprot Number:
O15123
Package Type:
Plastic Vial
Product Description:
Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
Purity:
>95% (SDS-PAGE)
Sequence:
Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag.
Source / Host:
HEK 293 cells
Specificity:
Binds to the human and mouse Tie-2 receptor.
TAGs:
FLAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

References

Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells: K.L. Kim, et al.; Cardiovasc. Res. 72, 394 (2006) | Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways: N. Liang, et al.; Int. J. Oncol. 51, 213 (2017)