Curcumin (high purity)
Product Code: AG-CN2-0059
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0059-M010 | 10 mg | £40.00 |
Quantity:
| AG-CN2-0059-M050 | 50 mg | £80.00 |
Quantity:
| AG-CN2-0059-M250 | 250 mg | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Further Information
Alternate Names/Synonyms:
BRN 2306965; CCRIS 3257; NSC 32982; NSC 687842; CI 75300
Appearance:
Yellow-orange crystalline powder.
CAS:
458-37-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Protect from light.
Hazards:
H302, H315, H319, H335
InChi:
InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChiKey:
VFLDPWHFBUODDF-FCXRPNKRSA-N
Long Description:
Chemical. CAS: 458-37-7. Formula: C21H20O6. MW: 368.4. Synthetic. Originally isolated from turmeric (Curcuma longa). Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Sonic hedgehog (Shh) signaling pathway modulator. Downregulates Shh and Gli1. Antioxidant. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS; NOSII). Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Potent immunomodulator. Modulates several key transcription factors. Down-regulate transcription factors NF-kappaB, AP-1 and Egr-1. Down-regulates the expression of COX-2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1. Down-regulate growth factor receptors (such as EGFR and HER2) and inhibits the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. Neuroprotective. Anti-amyloid activity. Cardioprotective. p300/CBP-HAT inhibitor. Regulates lipid metabolism and downregulates obesity. Activates peroxisome proliferator-activated receptor-gamma (PPARgamma) and Nrf2 cell-signaling pathways. Antiviral, antibacterial, antifungal. Epigenetic agent. Interacts with histone deacetylases (HDACs), histone acetyltransferases (HATs), DNA methyltransferase I and microRNAs. Inducer of autophagy in lung adenocarcinoma cells.
MDL:
MFCD00008365
Molecular Formula:
C21H20O6
Molecular Weight:
368.4
Other data:
Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4), tumorigenesis and development (Shh, Gli), metabolism (PPARgamma, Nrf2), epigenetics (HDACs, HATs, DNA methyltransferase I and microRNAs) and inflammation (NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Sonic hedgehog (Shh) signaling pathway modulator. Downregulates Shh and Gli1. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS; NOSII). Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Inhibits TLR4 and NLRP3 signaling. Modulates several key transcription factors. Down-regulate transcription factors NF-kappaB, AP-1 and Egr-1. Down-regulates the expression of COX-2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1. Down-regulate growth factor receptors (such as EGFR and HER2) and inhibits the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. Neuroprotective. Anti-amyloid activity. Cardioprotective. p300/CBP-HAT inhibitor. Regulates lipid metabolism and downregulates obesity. Activates peroxisome proliferator-activated receptor-gamma (PPARgamma) and Nrf2 cell-signaling pathways. Epigenetic agent. Interacts with histone deacetylases (HDACs), histone acetyltransferases (HATs), DNA methyltransferase I and microRNAs. Proteasome modulator/inhibitor.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
COC1=CC(C=CC(=O)CC(=O)C=CC2=CC(OC)=C(O)C=C2)=CC=C1O
Solubility Chemicals:
Soluble in methanol, ethanol, ethyl acetate, acetone, methylene chloride, dimethylformamide or methyl ethyl ketone.
Source / Host:
Synthetic. Originally isolated from turmeric (Curcuma longa).
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Anticancer potential of curcumin: preclinical and clinical studies: B.B. Aggarwal, et al.; Anticancer Res. 23, 363 (2003) (Review) | Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006) (Review) | Antioxidant and anti-inflammatory properties of curcumin: V.P. Menon & A.R. Sudheer; Adv. Exp. Med. Biol. 595, 105 (2007) (Review) | Modulation of transcription factors by curcumin: S. Shishodia, et al.; Adv. Exp. Med. Biol. 595, 127 (2007) (Review) | Antitumor, anti-invasion, and antimetastatic effects of curcumin: G. Kuttan, et al.; Adv. Exp. Med. Biol. 595, 173 (2007) (Review) | Neuroprotective effects of curcumin: G.M. Cole, et al.; Adv. Exp. Med. Biol. 595, 197 (2007) (Review) | Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases: B.B. Aggarwal & K.B. Harikumar; Int. J. Biochem. Cell Biol. 41, 40 (2009) (Review) | Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals: B.B. Aggarwal; Annu. Rev. Nutr. 30, 173 (2010) (Review) | Development of curcumin as an epigenetic agent: S. Fu & R. Kurzrock; Cancer 116, 4670 (2010) (Review) | The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer: F.H. Sarkar, et al.; Cancer Metastasis Rev. 29, 383 (2010) (Review) | Curcumin and obesity: evidence and mechanisms: L. Alappat & A.B. Awad; Nutr. Rev. 68, 729 (2010) (Review) | Curcumin: a potential neuroprotective agent in Parkinson's disease: R.B. Mythri & M.M. Bharath; Curr. Pharm. Des. 18, 91 (2012) (Review) | Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment: N. Hasima & B.B. Aggarwal; Curr. Med. Chem. 21, 1583 (2014) | Curcumin as a MicroRNA Regulator in Cancer: A Review: A.A. Momtazi, et al.; Rev. Physiol. Biochem. Pharmacol. 171, 1 (2016) (Review) | Curcumin: A Natural Pan-HDAC Inhibitor in Cancer: S.S. Soflaei, et al.; Curr. Pharm. Des. 24, 123 (2018) (Review) | Impact of curcumin on toll-like receptors: M. Boozari, et al.; J. Cell Physiol. 234, 12471 (2019) (Review) | Curcumin: a modulator of inflammatory signaling pathways in the immune system: K.R. Kahkhaie, et al.; Inflammopharmacol. 27, 885 (2019) (Review) | Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies: D.J.Den Hartogh, et al.; Nutrients 12, 118 (2020) (Review) | Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies: D.J.Den Hartogh, et al.; Nutrients 12, 58 (2020) (Review) | The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties: M.A. Panaro, et al.; Int. J. Mol. Sci. 21, 2299 (2020) (Review) | Curcumin as an Antiviral Agent: M.R. Jennings & R.J. Parks; Viruses 12, 1242 (2020) (Review) | COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin? A.Saeedi-Boroujeni, et al.; Basic. Clin. Pharmacol. Toxicol. 128, 37 (2021) (Review)