Lariatin A
Product Code: AG-CN2-0120
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0120-C250 | 250 ug | £115.00 |
Quantity:
| AG-CN2-0120-M001 | 1 mg | £325.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
GSQLVYREWVGHSNVIKP; H-Gly-Ser-Gln-Leu-Val-Tyr-Arg-Glu-Trp-Val-Gly-His-Ser-Asn-Val-Ile-Lys-Pro-OH
Appearance:
Off-white solid.
CAS:
732286-09-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H302, H312, H332
InChi:
InChI=1S/C94H143N27O25/c1-11-50(10)77(91(143)111-60(20-14-15-31-95)92(144)121-33-17-22-68(121)93(145)146)120-90(142)76(49(8)9)119-85(137)65(38-70(97)126)114-87(139)67(44-123)116-82(134)64(37-53-40-100-45-105-53)106-73(129)42-104-88(140)74(47(4)5)117-84(136)63(36-52-39-102-56-19-13-12-18-55(52)56)113-80(132)59-28-30-71(127)103-41-72(128)107-66(43-122)86(138)110-58(27-29-69(96)125)79(131)112-61(34-46(2)3)83(135)118-75(48(6)7)89(141)115-62(35-51-23-25-54(124)26-24-51)81(133)108-57(78(130)109-59)21-16-32-101-94(98)99/h12-13,18-19,23-26,39-40,45-50,57-68,74-77,102,122-124H,11,14-17,20-22,27-38,41-44,95H2,1-10H3,(H2,96,125)(H2,97,126)(H,100,105)(H,103,127)(H,104,140)(H,106,129)(H,107,128)(H,108,133)(H,109,130)(H,110,138)(H,111,143)(H,112,131)(H,113,132)(H,114,139)(H,115,141)(H,116,134)(H,117,136)(H,118,135)(H,119,137)(H,120,142)(H,145,146)(H4,98,99,101)/t50-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,74-,75-,76-,77-/m0/s1
InChiKey:
ZYWDOXCVVHITIW-KBACZRJDSA-N
Long Description:
Chemical. CAS: 732286-09-8. Formula: C94H143N27O25. MW: 2051.4. Isolated from Rhodococcus jostii. Peptide with lasso structure. Antimycobacterial.
Molecular Formula:
C94H143N27O25
Molecular Weight:
2051.4
Package Type:
Vial
Precautions:
P261, P301, P312, P302, P352, P304, P340
Product Description:
Peptide with lasso structure. Antimycobacterial.
Purity:
>95% (HPLC)
Signal word:
Warning
SMILES:
[H]N([C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(O)=O)C(=O)C1CCC(=O)N([H])CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N([H])[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@H](CCCNC(N)=N)C(=O)N1
Solubility Chemicals:
Soluble in methanol or water.
Source / Host:
Isolated from Rhodococcus jostii.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.
References
Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure: M. Iwatsuki, et al.; JACS 128, 7486 (2006) | Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171: M. Iwatsuki, et al.; J. Antibiot. (Tokyo) 60, 357 (2007) | Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity: M. Iwatsuki, et al.; Bioorg. Med. Chem. Lett. 19, 2888 (2009) | Molecular cloning of the gene cluster for lariatin biosynthesis of Rhodococcus jostii K01-B0171: J. Inokoshi, et al.; Appl. Microbiol. Biotechnol. 95, 451 (2012)