3,28-Di-O-(3,3-dimethylglutaryl)betulin
| Code | Size | Price |
|---|
| BVT-0404-M001 | 1 mg | £110.00 |
Quantity:
| BVT-0404-M005 | 5 mg | £315.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
3,28-di(diMeG)betulin; NSC705961; Betulin 3,28-(3,3-dimethyl)glutarate
Appearance:
White to off-white solid. This substance is hygroscopic and might gradually change its state of aggregation from solid to oil.
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Very hygroscopic.
Hazards:
H302
InChi:
InChI=1/C44H70O8/c1-27(2)28-14-19-44(26-51-35(49)24-38(3,4)22-33(45)46)21-20-42(10)29(37(28)44)12-13-31-41(9)17-16-32(40(7,8)30(41)15-18-43(31,42)11)52-36(50)25-39(5,6)23-34(47)48/h28-32,37H,1,12-26H2,2-11H3,(H,45,46)(H,47,48)/t28-,29+,30-,31+,32-,37+,41-,42+,43+,44?/m0/s1
InChiKey:
MPCSQAWQRMXLDD-GVCIVQAHBD
Long Description:
Chemical. Formula: C44H70O8. MW: 727. Semi-synthetic derivative from betulin (from birch bark). Semi-synthetic derivative of betulin (from birch bark). Potent antiviral compound. Shows anti-HIV activity (more active than AZT in vitro).
Molecular Formula:
C44H70O8
Molecular Weight:
727
Package Type:
Plastic Vial
Precautions:
P264, P270, P301, P312
Product Description:
Semi-synthetic derivative of betulin (from birch bark). Potent antiviral compound. Shows anti-HIV activity (more active than AZT in vitro).
Purity:
>97% (HPLC)
Signal word:
Warning
SMILES:
[H][C@]12[C@@H](CCC1(COC(=O)CC(C)(C)CC(O)=O)CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CC(C)(C)CC(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(C)=C
Solubility Chemicals:
Soluble in methanol, acetone or DMSO.
Source / Host:
Semi-synthetic derivative from betulin (from birch bark).
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
References
Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives: I.-C. Sun, et al.; Bioorg. Med. Chem. Lett. 8, 1267 (1998) | Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents: I.-C. Sun, et al.; J. Med. Chem. 41, 4648 (1998) | 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents: Y. Kashiwada, et al.; Bioorg. Med. Chem. Lett. 11, 183 (2001) | 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents: Y. Kashiwada, et al.; Bioorg. Med. Chem. Lett. 14, 5851 (2004) | Birch bark research and development: P.A. Krasutsky; Nat. Prod. Rep. 23, 919 (2006) | Pharmacological properties of the ubiquitous natural product betulin: S. Alakurtti, et al.; Eur. Pharm. Sci. 29, 1 (2006)