4alpha-PMA
Product Code: AG-CN2-0082
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0082-M001 | 1 mg | £70.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
4alpha-PMA; 4alpha-TPA; 4alpha-12-O-Tetradecanoylphorbol 13-acetate
Appearance:
White to off-white solid.
CAS:
63597-44-4
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34+,35-,36-/m1/s1
InChiKey:
PHEDXBVPIONUQT-LQLWEASQSA-N
Long Description:
Chemical. CAS: 63597-44-4. Formula: C36H56O8. MW: 616.8. Semi-synthetic. Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010). Might be a reasonable PKC-independent TRPV4 channels agonist.
MDL:
MFCD00153860
Molecular Formula:
C36H56O8
Molecular Weight:
616.8
Package Type:
Vial
Product Description:
Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010) [1-6]. Might be a reasonable PKC-independent TRPV4 channels agonist [5].
Purity:
>98% (HPLC)
SMILES:
[H][C@]12[C@]3([H])C=C(CO)C[C@@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCCCCCC)[C@@]1(OC(C)=O)C2(C)C
Solubility Chemicals:
Soluble in DMSO, ehanol, methanol or ethyl acetate.
Source / Host:
Semi-synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin: B.L. Van Duuren et al.; Cancer Res. 39, 2644 (1979) | Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation: M. Thivierge, et al.; J. Immunol. 157, 4681 (1996) | Integrin ligation and PKC activation are required for migration of colon carcinoma cells: V. Rigot, et al.; J. Cell Sci. 111, 3119 (1998) | Activated protein kinase C isoforms target to cardiomyocyte caveolae: stimulation of local protein phosphorylation: V.O. Rybin, et al.; Circ. Res. 84, 980 (1999) | Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4: F. Xu, et al.; Br. J. Pharmacol. 140, 413 (2003) | Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva, et al; Eur. J. Pharmacol. 491, 101 (2004)