Piceatannol

Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor: R.L. Geahlen, et al.; BBRC 165, 241 (1989) | Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol: J.M. Oliver, et al.; J. Biol. Chem. 269, 29697 (1994) | Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol: B.H. Wang, et al.; Planta Med. 64, 195 (1998) | Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol: L. Su & M. David; J. Biol. Chem. 275, 12661 (2000) | Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts: T. Wieder, et al.; Leukemia 15, 1735 (2001) | Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines: F. Wolter, et al.; J. Nutr. 132, 298 (2002) | Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation: K. Ashikawa, et al.; J. Immunol. 169, 6490 (2002) | Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) | Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways: B.S. Wung, et al.; Pharmacol. Res. 53, 113 (2006) | Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines: Z. Ovesna, et al.; Oncol. Rep. 16, 617 (2006) | Protective effects of piceatannol against beta-amyloid-induced neuronal cell death: H.J. Kim, et al.; Ann. N Y Acad. Sci. 1095, 473 (2007) | Piceatannol inhibits melanogenesis by its antioxidative actions: T. Yokozawa & Y.J. Kim; Biol. Pharm. Bull. 30, 2007 (2007) | Induction of apoptosis by piceatannol in human leukemic U937 cells through down-regulation of Bcl-2 and activation of caspases: Y.H. Kim, et al.; Oncol. Rep. 19, 961 (2008) | Piceatannol attenuates 4-hydroxynonenal-induced apoptosis of PC12 cells by blocking activation of c-Jun N-terminal kinase: Y.J. Jang, et al.; Ann. N Y Acad. Sci. 1171, 176 (2009) | Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells: K.H. Choi, et al.; Cardiovasc. Res. 85, 836 (2010) | Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling: G.T. Kwon, et al.; J. Nutr. Biochem. 23, 228 (2012) | Biological activity of piceatannol: leaving the shadow of resveratrol: H. Piotrowska, et al.; Mutat. Res. 750, 60 (2012) (Review) | Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation: J.Y. Kwon, et al.; J. Biol. Chem. 287, 11566 (2012) | Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells: Y. Kita, et al.; J. Biomed. Biotechnol. 2012, 672416 (2012) | Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice: M. Minakawa, et al.; BBRC 422, 469 (2012) | Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins: F. Pietrocola, et al.; Cell Cycle 11, 3851 (2012)