Amidepsine D
Product Code: AG-CN2-0110
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0110-M001 | 1 mg | £230.00 |
Quantity:
| AG-CN2-0110-MM25 | 2.5 mg | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Appearance:
White to light pink powder.
CAS:
79786-34-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H302, H312, H332
InChi:
InChI=1S/C26H24O10/c1-12-7-16(9-18(27)21(12)24(29)30)35-25(31)22-13(2)8-17(10-19(22)28)36-26(32)23-14(3)6-15(33-4)11-20(23)34-5/h6-11,27-28H,1-5H3,(H,29,30)
InChiKey:
KODVVMZOLYYCMV-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 79786-34-8. Formula: C26H24O10. MW: 496.5. Isolated from Humcola sp. FO-2942. Diacylglycerol acyltransferase (DGAT) inhibitor. Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
MDL:
MFCD28138426
Molecular Formula:
C26H24O10
Molecular Weight:
496.5
Package Type:
Vial
Precautions:
P261, P301, P312, P302, P352, P304, P340
Product Description:
Diacylglycerol acyltransferase (DGAT) inhibitor [1-4]. Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Purity:
>95% (HPLC)
Signal word:
Warning
SMILES:
COC1=CC(OC)=C(C(=O)OC2=CC(C)=C(C(=O)OC3=CC(C)=C(C(O)=O)C(O)=C3)C(O)=C2)C(C)=C1
Solubility Chemicals:
Soluble in methanol, benzene or ethyl acetate. Insoluble in water or hexane.
Source / Host:
Isolated from Humcola sp. FO-2942.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) | Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) | Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969: H. Tomoda, et al.; J. Antibiot. 49, 929 (1996) | Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007)
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