Streptochlorin
Product Code: AG-CN2-0141
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0141-C250 | 250 ug | £85.00 |
Quantity:
| AG-CN2-0141-M001 | 1 mg | £235.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
SF 2583A; 12815A; 4-Chloro-5-(3-indolyl)oxazole; 3-(4-Chloro-5-oxazolyl)-1H-indole
Appearance:
Crystalline solid.
CAS:
120191-51-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H302, H312, H332
InChi:
InChI=1S/C11H7ClN2O/c12-11-10(15-6-14-11)8-5-13-9-4-2-1-3-7(8)9/h1-6,13H
InChiKey:
BKYJGKRXUHPPLR-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 120191-51-7. Formula: C11H7ClN2O. MW: 218.6. Isolated from Streptomyces roseolilacinus. Antibiotic. TNF-alpha-induced NF-kappaB activation inhibitor. Antiangiogenic. Apoptosis inducer. Anticancer compound. Selective cytotoxic against several cancer cell lines. Tyrosinase inhibitor.
MDL:
MFCD18449873
Molecular Formula:
C11H7ClN2O
Molecular Weight:
218.6
Package Type:
Vial
Precautions:
P261, P301, P312, P302, P352, P304, P340
Product Description:
Antibiotic [1]. TNF-alpha-induced NF-kappaB activation inhibitor [1]. Antiangiogenic [1]. Apoptosis inducer [2-4]. Anticancer compound. Selective cytotoxic against several cancer cell lines [2-4]. Tyrosinase inhibitor [5].
Purity:
>95% (HPLC)
Signal word:
Warning
SMILES:
ClC1=C(OC=N1)C1=CNC2=CC=CC=C12
Solubility Chemicals:
Soluble in DMSO or methanol. Insoluble in water or hexane.
Source / Host:
Isolated from Streptomyces roseolilacinus.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Streptochlorin, a marine natural product, inhibits NF-kappaB activation and suppresses angiogenesis in vitro: I. K. Choi, et al.; J. Microbiol. Biotechnol. 17, 1338 (2007) | Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110: H. J. Shin, et al.; J. Microbiol. Biotechnol. 17, 1403 (2007) | Streptochlorin isolated from Streptomyces sp. induces apoptosis in human hepatocarcinoma cells through a reactive oxygen species-mediated mitochondrial pathway: D. Y. Shin, et al.; J. Microbiol. Biotechnol. 18, 1862 (2008) | Induction of apoptosis by streptochlorin isolated from Streptomyces sp. in human leukemic U937 cells: C. Park, et al.; Toxicol. In Vitro 22, 1573 (2008) | Physicochemical characters of a tyrosinase inhibitor produced by Streptomyces roseolilacinus NBRC 12815: T. Nakashima, et al.; Biol. Pharm. Bull. 32, 832 (2009)
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