Territrem B
Product Code: AG-CN2-0142
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0142-C500 | 500 ug | £125.00 |
Quantity:
| AG-CN2-0142-M001 | 1 mg | £220.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Appearance:
White solid.
CAS:
70407-20-4
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Handling Advice:
Keep cool and dry.
Hazards:
H301, H311, H330
InChi:
InChI=1S/C29H34O9/c1-25(2)9-8-22(30)27(4)28(25,32)11-10-26(3)29(27,33)15-17-19(38-26)14-18(37-24(17)31)16-12-20(34-5)23(36-7)21(13-16)35-6/h8-9,12-14,32-33H,10-11,15H2,1-7H3/t26-,27+,28-,29-/m1/s1
InChiKey:
PBXNNDFKPQPJBB-VJLHXPKFSA-N
Long Description:
Chemical. CAS: 70407-20-4. Formula: C29H34O9. MW: 526.6. Synthetic. Originally isolated from Aspergillus terreus. Tremorgenic mycotoxin. Potent and specific, irreversible acetylcholinesterase (AChE) inhibitor.
MDL:
MFCD00869655
Molecular Formula:
C29H34O9
Molecular Weight:
526.6
Package Type:
Vial
PG:
III
Precautions:
P301, P310, P302, P352, P304, P340, P330
Product Description:
Tremorgenic mycotoxin [1, 2]. Potent and specific, irreversible acetylcholinesterase (AChE) inhibitor [3-7].
Purity:
>95% (HPLC)
Signal word:
Danger
SMILES:
COC1=CC(=CC(OC)=C1OC)C1=CC2=C(C[C@@]3(O)[C@@](C)(CC[C@@]4(O)C(C)(C)C=CC(=O)[C@]34C)O2)C(=O)O1
Solubility Chemicals:
Soluble in methanol or chloroform. Insoluble in water.
Source / Host:
Synthetic. Originally isolated from Aspergillus terreus.
Transportation:
Excepted Quantity
UN Nummer:
UN 3462
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Territrems, tremorgenic mycotoxins of Aspergillus terreus: K.H. Ling, et al.; Appl. Environ. Microbiol. 37, 355 (1979) | Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem B' from Aspergillus terreus: F.C. Peng, et al.; Appl. Environ. Microbiol. 49, 721 (1985) | Effects of territrem-B on cholinergic responses of snail neuron: V.L. Arvanov, et al.; Neurosci. Lett. 152, 69 (1993) | Acetylcholinesterase inhibition by territrem B derivatives: F.C. Peng; J. Nat. Prod. 58, 857 (1995) | Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase: J.W. Chen & K.H. Ling; J. Biomed. Sci. 3, 54 (1996) | Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity: F. Kuno, et al.; J. Antibiot. 49, 742 (1996) | Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism: J.W. Chen, et al.; J. Biol. Chem. 274, 34916 (1999)
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