PLX4720
| Code | Size | Price |
|---|
| AG-CR1-3577-M005 | 5 mg | £95.00 |
Quantity:
| AG-CR1-3577-M025 | 25 mg | £265.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Appearance:
Off-white solid.
CAS:
918505-84-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
InChiKey:
YZDJQTHVDDOVHR-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 918505-84-7. Formula: C17H14ClF2N3O3S. MW: 413.8. Synthetic. Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.
MDL:
MFCD14635203
Molecular Formula:
C17H14ClF2N3O3S
Molecular Weight:
413.8
Package Type:
Vial
Product Description:
Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.
Purity:
>99% (HPLC)
SMILES:
CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=CNC3=NC=C(Cl)C=C23)=C1F
Solubility Chemicals:
Soluble in DMSO or ethanol.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity: J. Tsai, et al.; PNAS 105, 3041(2008) | Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival: R.A. Cartlidge, et al.; Pigment Cell Melanoma Res. 21, 534 (2008) | Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma: L.M. Packer, et al.; Pigment Cell Melanoma Res. 22, 785 (2009) | Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells: P. Salerno, et al.; J. Clin. Endocrinol. Metab. 95, 450 (2010) | B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression: C. Nucera, et al.; PNAS 107, 10649 (2010) | Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS: C.C. Jiang, et al.; Cell Death Dis. 1, e69 (2010) | Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer: C. Nucera, et al.; Oncologist 16, 296 (2011)
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