OM173-alphaA
Product Code: AG-CN2-0158
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0158-M001 | 1 mg | £190.00 |
Quantity:
| AG-CN2-0158-M005 | 5 mg | £750.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Nanaomycin alphaA
Appearance:
Yellow solid.
CAS:
58286-56-9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H302, H312, H319
InChi:
InChI=1S/C17H16O6/c1-8-14-11(6-9(23-8)7-13(19)22-2)16(20)10-4-3-5-12(18)15(10)17(14)21/h3-5,8-9,18H,6-7H2,1-2H3/t8-,9+/m0/s1
InChiKey:
FMEUWIKCSICJBO-DTWKUNHWSA-N
Long Description:
Chemical. CAS: 58286-56-9. Formula: C17H16O6. MW: 316.3. Isolated from Streptomyces sp. Antibiotic. Antimycoplasma. Antifungal compound. Anti-malarial agent. Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor. Potential anticancer compound. Inducer of antiproliferative effects in tumor cell lines. Selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor.
MDL:
MFCD28899099
Molecular Formula:
C17H16O6
Molecular Weight:
316.3
Package Type:
Vial
Precautions:
P270, P280, P301, P312, P302, P352, P312
Product Description:
Antibiotic [1-3]. Antimycoplasma [1, 3, 4]. Antifungal compound [1, 3]. Anti-malarial agent [5]. Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor [6]. Potential anticancer compound. Inducer of antiproliferative effects in tumor cell lines [6-8]. Selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor [8].
Purity:
>95% (HPLC)
Signal word:
Warning
SMILES:
COC(=O)C[C@H]1CC2=C([C@H](C)O1)C(=O)C1=C(O)C=CC=C1C2=O
Solubility Chemicals:
Soluble in DMSO, ethanol or methanol.
Source / Host:
Isolated from Streptomyces sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties: H. Tanaka, et al.; J. Antibiot. 28, 860 (1975) | Nanomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis: H. Tanaka, et al.; J. Antibiot. 28, 868 (1975) | Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanaomycin C, and biological activities of nanaomycin derivatives: H. Tanaka, et al.; J. Antibiot. 28, 925 (1975) | OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties: Y. Iway, et al.; J. Antibiot. 36, 1268 (1983) | Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol: Y. Tanaka, et al.; J. Antibiot. 52, 880 (1999) | UCF76 compounds, new inhibitors of farnesyltransferase produced by Streptomyces: M. Hara, et al.; J. Antibiot. 54, 182 (2001) | Total synthesis and development of bioactive natural products: T. Kuniaki; Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 84, 87 (2008) | Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells: D. Kuck, et al.; Mol. Cancer Ther. 9, 3015 (2010)
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