Actinonin
Product Code: AG-CN2-0161
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0161-M005 | 5 mg | £100.00 |
Quantity:
| AG-CN2-0161-M025 | 25 mg | £370.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(-)-Actinonin; CONA 57; Ro 06-1467
Appearance:
White solid.
CAS:
13434-13-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
InChiKey:
XJLATMLVMSFZBN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 13434-13-4. Formula: C19H35N3O5. MW: 385.5. Synthetic. Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14. Anticancer compound. Antiproliferative. Shows antitumor activity in vitro and in vivo Apoptosis inducer. Meprin A inhibitor.
MDL:
MFCD00058569
Molecular Formula:
C19H35N3O5
Molecular Weight:
385.5
Package Type:
Vial
Product Description:
Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14. Anticancer compound. Antiproliferative. Shows antitumor activity in vitro and in vivo. Apoptosis inducer. Meprin A inhibitor.
Purity:
>97.0% (HPLC)
SMILES:
CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
Solubility Chemicals:
Soluble in DMSO or ethanol.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Actinonin: an antibiotic substance produced by an actinomycete: J.J. Gordon, et al.; Nature 195, 701 (1962) | Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes: H. Umezawa, et al.; J. Antibiot. 38, 1629 (1985) | Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes: M. Hachisu, et al.; Life Sci. 41, 235 (1987) | Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998) | Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000) | A new human peptide deformylase inhibitable by actinonin: M.D. Lee, et al.; Biochem. Biophys. Res. Comm. 312, 309 (2003) | Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2004) | Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics: M.D. Lee, et al.; J. Clin. Invest. 114, 1107 (2004) | Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats: J. Takayama, et al.; Eur. J. Pharmacol. 581, 157 (2007) | Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis: Z. Whang, et al.; Shock 35, 141 (2011)
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