Betulinic acid (>97%)

AdipoGen Life Sciences
Product Code: AG-CN2-0417
CodeSizePrice
AG-CN2-0417-M100100 mg£60.00
Quantity:
AG-CN2-0417-M500500 mg£200.00
Quantity:
AG-CN2-0417-G0011 g£285.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C

Images

1 / 1
Chemical Structure

Chemical Structure

Further Information

Alternate Names/Synonyms:
3beta-Hydroxy-20(29)-lupaene-28-oic acid
Appearance:
White to off-white solid.
CAS:
472-15-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
InChiKey:
QGJZLNKBHJESQX-FZFNOLFKSA-N
Long Description:
Chemical. CAS: 472-15-1. Formula: C30H48O3. MW: 456.7. Isolated from Platanus acerifolia bark. Anti-HIV compound. Anticancer compound. Apoptosis inducer. Modulator of NF-kappaB. Potent DNA topoisomerase II inhibitor. Potent proteasome activator. Antimalarial compound.
MDL:
MFCD00009619
Molecular Formula:
C30H48O3
Molecular Weight:
456.7
Package Type:
Vial
Product Description:
Anti-HIV compound [1]. Anticancer compound [2]. Apoptosis inducer [2]. Modulator of NF-kappaB [3,4,8]. Potent DNA topoisomerase II inhibitor [5]. Potent proteasome activator [6]. Antimalarial compound [7].
Purity:
>97% (HPLC)
SMILES:
[H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C
Solubility Chemicals:
Soluble in DMSO.
Source / Host:
Isolated from Platanus acerifolia bark.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids: T. Fujioka, et al.; J. Nat. Prod. 57, 243 (1994) | Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis: E. Pisha, et al.; Nat. Med. 1, 1046 (1995) | Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9: Y. Takada & B.B. Aggarwal: J. Immunol. 171, 3278 (2003) | Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy: H. Kasperczyk, et al.; Oncogene 24, 6945 (2005) | Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica: S. Wada & R. Tanaka; Chem. Biodivers. 2, 689 (2005) | Activation and inhibition of the proteasome by betulinic acid and its derivatives: L. Huang, et al.; FEBS Lett. 581, 4955 (2007) | Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice: M.S. de Sa, et al.; Parasitol. Res. 105, 275 (2009) | Betulinic acid, a natural compound with potent anticancer effects: F.B. Mullauer, et al.; Anticancer Drugs 21, 215 (2010)

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