Pimprinine
| Code | Size | Price |
|---|
| BVT-0297-M001 | 1 mg | £150.00 |
Quantity:
| BVT-0297-M005 | 5 mg | £425.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
3-(2-Methyl-5-oxazolyl)-1H-indole; Antibiotic WS-30581C; NSC80793; 5-(3-Indoyl)-2-methyloxazole
Appearance:
Pale yellow to beige powder.
CAS:
13640-26-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H302, H312, H319
InChi:
InChI=1S/C12H10N2O/c1-8-13-7-12(15-8)10-6-14-11-5-3-2-4-9(10)11/h2-7,14H,1H3
InChiKey:
WZJPGCHCOHYLMB-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 13640-26-1. Formula: C12H10N2O. MW: 198.2. Isolated from Streptomyces sp. Indole alkaloid. Monoamine oxidase inhibitor (MAOI). Antiepileptic (anticonvulsant) compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.
MDL:
MFCD08061896
Molecular Formula:
C12H10N2O
Molecular Weight:
198.2
Package Type:
Plastic Vial
Precautions:
P270, P280, P301, P312, P302, P352, P312
Product Description:
Indole alkaloid. Monoamine oxidase inhibitor (MAOI). Antiepileptic (anticonvulsant) compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.
Purity:
>98% (HPLC, NMR)
Signal word:
Warning
SMILES:
CC1=NC=C(O1)C1=CNC2=CC=CC=C12
Solubility Chemicals:
Soluble in DMSO, methanol or acetone.
Source / Host:
Isolated from Streptomyces sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
The structure and synthesis of pimprinine: B.S. Joshi, et al.; Tetrahedron 19, 1437 (1963) | Pimprinine in the treatment of hyperkinetic diseases: M.J. Narasimhan Jr. & V.G. Ganla; Hindustan Antibiot. Bull. 9, 138 (1967) | Monoamine oxidase inhibitors isolated from fermented broths: T. Takeuchi, et al.; J. Antibiot. 26, 162 (1973) | Studies on new antiplatelet agents, WS-30581 A and B: K. Umehara, et al.; J. Antibiot. 10, 1153 (1984) | Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity: S.R. Naik, et al.; J. Biotechnol. 88, 1 (2001) | Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924: C. Intaraudom, et al.; Tetrahedron 67, 7593 (2011) | Synthesis and fungicidal activity of novel pimprinine analogues: M.-Z. Zhang, et al.; Eur. J. Med. Chem. 53, 283 (2012)
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