TRAF2 Antibody

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ProSci
Product Code: PSI-3661
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-3661-0.02mg0.02mg£150.00
Quantity:
PSI-3661-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of TRAF2 in mouse liver tissue lysate with TRAF2 antibody at 1 μg/mL.
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Immunohistochemistry of TRAF2 in mouse liver tissue with TRAF2 antibody at 10 μg/mL.
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Western blot analysis of TRAF2 in mouse liver tissue lysate with TRAF2 antibody at 1 μg/mL.
Immunohistochemistry of TRAF2 in mouse liver tissue with TRAF2 antibody at 10 μg/mL.

Documents

Further Information

Additional Names:
TRAF2 Antibody: TRAP, TRAP3, MGC:45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2
Application Note:
TRAF2 antibody can be used for the detection of TRAF2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Background:
TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-κB activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
Background References:
  • Arch RH, Gedrich RW, and Thompson CB. Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adaptor proteins that regulate life and death. Genes Dev.1998; 12:2821-30.
  • van Kooten C and Bancherau J. CD40-CD40 ligand. J. Leukoc. Biol.2000; 67:2-17.
  • Grech AP, Amesbury M, Chan T, et al. TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity2004; 21:629-42.
  • Davies CC, Mak TW, Young LS, et al. TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol. Cell. Biol.2005; 25:9806-19.
Buffer:
TRAF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TRAF2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TRAF2.

The immunogen is located within the last 50 amino acids of TRAF2.
NCBI Gene ID #:
7186
NCBI Official Name:
TNF receptor-associated factor 2
NCBI Official Symbol:
TRAF2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 53 kDa
Protein Accession #:
CAI15106
Protein GI Number:
55959980
Purification:
TRAF2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction,Cancer
Swissprot #:
Q12933
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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