6-Amino-8-trifluoromethylphenanthridine
| Code | Size | Price |
|---|
| AG-MR-C0031-M001 | 1 mg | £70.00 |
Quantity:
| AG-MR-C0031-M005 | 5 mg | £160.00 |
Quantity:
| AG-MR-C0031-M025 | 25 mg | £430.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
6A-8tFP; 8-Trifluoromethyl-6-aminophenanthridine
Appearance:
Beige solid.
CAS:
651055-83-3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.
Hazards:
H319
InChi:
InChI=1S/C14H9F3N2/c15-14(16,17)8-5-6-9-10-3-1-2-4-12(10)19-13(18)11(9)7-8/h1-7H,(H2,18,19)
InChiKey:
VBQYJKNVRUTAHL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 651055-83-3. Formula: C14H9F3N2. MW: 262.2. Potent antiprion agent. Higher activity than 6-Aminophenanthridine (Prod. No. MC-C0029). Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.
MDL:
MFCD30294025
Molecular Formula:
C14H9F3N2
Molecular Weight:
262.2
Package Type:
Vial
Precautions:
P280, P305, P351, P338
Product Description:
Potent antiprion agent. Higher activity than 6-Aminophenanthridine (Prod. No. MC-C0029). Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.
Purity:
>99% (NMR)
Signal word:
Warning
SMILES:
NC1=NC2=C(C=CC=C2)C2=C1C=C(C=C2)C(F)(F)F
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Isolation of drugs active against mammalian prions using a yeast-based screening assay: S. Bach, et al.; Nat. Biotechnol. 21, 1075 (2003) | A single step synthesis of 6-aminophenanthridines from anilines and 2-chlorobenzonitriles: F. Gug, et al.; THL 60, 4705 (2004)
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