Asiatic acid

Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells: Y.L. Hsu, et al.; J. Pharmacol. Exp. Ther. 313, 333 (2005) | Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice: J. Gao, et al.; J. Pharm. Pharmacol. 58, 227 (2006) | Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid: G.M. Gurfinkel, et al.; Apoptosis 11, 1463 (2006) | Structure-activity relationship study of asiatic acid derivatives for new wound healing agent: B.S. Jeong; Arch. Pharm. Res. 29, 556 (2006) | Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade: X.L. Tang, et al.; Biol. Pharm. Bull. 32, 1399 (2009) | Synthesis and biological evaluation of asiatic acid derivatives as inhibitors of glycogen phosphorylases: L. Zhang, et al.; Chem. Biodivers. 6, 864 (2009) | Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance: S.P. Patil, et al.; J. Nat. Prod. 73, 1196 (2010) | Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats: J. Liu, et al.; Diabetes Metab. Res. Rev. 26, 448 (2010) | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice: S.S. Huang, et al.; Evid. Based Complement Alternat. Med. 2011, 895857 (2011) | Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models: C.V. Kavitha, et al.; PLoS One 6, e22745 (2011) | Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity: M.N. Nasir, et al.; Phytomedicine 19, 311 (2012) | Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro: L.X. Tang, et al.; PLoS One 7, e31350 (2012) | Asiatic acid attenuates infarct volume, mitochondrial dysfunction, and matrix metalloproteinase-9 induction after focal cerebral ischemia: K.Y. Lee, et al.; Stroke 43, 1632 (2012) | Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats: V. Ramachandran & R. Saravanan; Phytomedicine 20, 230 (2013) | Asiatic Acid Inhibits Adipogenic Differentiation of Bone Marrow Stromal Cells: Z.W. Li, et al.; Cell Biochem. Biophys. 68, 437 (2014)