anti-CARMA1 pAb (AL220)
| Code | Size | Price |
|---|
| AG-25B-0004V-C100 | 100 ug | £270.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
CARD11; Bimp3; Caspase Recruitment Domain-containing Protein 11; CARD-containing MAGUK Protein 1
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
N-terminal human CARMA1 (aa 1-221 containing the CARD domain).
Long Description:
Polyclonal Antibody. Recognizes human and mouse CARMA1. Detects a band of ~130Dka by Western blot. Source: Rabbit. Applications: ICC, IHC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. CARMA1 is involved in the costimulatory signal essential for T cell receptor (TCR)-mediated T cell activation. Its binding to DPP4 induces T cell proliferation and NF-kappaB activation in a T cell receptor/CD3-dependent manner. CARMA1 activates NF-kappaB via Bcl10 and IKK.
NCBI, Uniprot Number:
Q9BXL7
Other data:
This purified antiserum is replacing the product AG-25B-0004 CARMA1 pAb (AL220) (neat antiserum) with same specifications.
Package Type:
Plastic Vial
Product Description:
CARMA1 is involved in the costimulatory signal essential for T cell receptor (TCR)-mediated T cell activation. Its binding to DPP4 induces T cell proliferation and NF-kappaB activation in a T cell receptor/CD3-dependent manner. CARMA1 activates NF-kappaB via Bcl10 and IKK.
Source / Host:
Rabbit
Specificity:
Recognizes human and mouse CARMA1. Detects a band of ~130Dka by Western blot.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation: O. Gaide, et al.; Nat. Immunol. 3, 836 (2002) | MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappaB-dependent proliferative advantage and resistance against FAS-induced cell death in B cells: L. Ho, et al.; Blood 105, 2891 (2005) | Phosphorylation of the CARMA1 Linker Controls NF-kappaB Activation: K. Sommer, et al.; Immunity 23, 561 (2005) | Overexpression of Caspase Recruitment Domain (CARD) Membrane-Associated Guanylate Kinase 1 (CARMA1) and CARD9 in Primary Gastric B-Cell Lymphoma: S. Nakamura, et al.; Cancer 104, 1885 (2005) | Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1: R.B. Medeiros, et al.; Science 316, 754 (2007) | Bcl10 Controls TCR- and FcgammaR-Induced Actin Polymerization: D. Rueda, et al.; J. Immunol. 178, 4373 (2007) | The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008) | MAGUK-Controlled Ubiquitination of CARMA1 Modulates Lymphocyte NF-kappaB Activity: M.E. Moreno-Garcia, et al.; Mol. Cell Biol. 30, 922 (2010) | Interaction of calmodulin with Bcl10 modulates NF-kappaB activation: S. Edin, et al.; Mol. Immunol. 47, 2057 (2010)