Compound 112254
| Code | Size | Price |
|---|
| AG-CR1-0155-M010 | 10 mg | £85.00 |
Quantity:
| AG-CR1-0155-M050 | 50 mg | £305.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
4-(tert-Butyl)-N-(3-(4-(4-methoxybenzyl)piperazin-1-yl)-3-oxopropyl)benzamide
Appearance:
White crystalline solid.
CAS:
949745-75-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C26H35N3O3/c1-26(2,3)22-9-7-21(8-10-22)25(31)27-14-13-24(30)29-17-15-28(16-18-29)19-20-5-11-23(32-4)12-6-20/h5-12H,13-19H2,1-4H3,(H,27,31)
InChiKey:
XBEMZEZVTNPLQI-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 949745-75-9. Formula: C26H35N3O3. MW: 437.6. Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon (Prod. No. AG-CR1-0154) http://www.adipogen.com/ag-cr1-0154/adiporon.html . Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms.
MDL:
MFCD10526919
Molecular Formula:
C26H35N3O3
Molecular Weight:
437.6
Package Type:
Vial
Product Description:
Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon (Prod. No. AG-CR1-0154) http://www.adipogen.com/ag-cr1-0154/adiporon.html [1, 2]. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells [1]. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms [1].
Purity:
>98% (NMR)
SMILES:
COC1=CC=C(CN2CCN(CC2)C(=O)CCNC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1
Solubility Chemicals:
Soluble in DMSO, 100% ethanol, methanol or dichloromethane. Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity: M. Okada-Iwabu, et al.; Nature 503, 493 (2013) | Cell Biology. Ronning after the adiponectin receptors: W.L. Holland & P.E. Scherer; Science 342, 1460 (2013)
Related Products
| Product Name | Product Code | Supplier | AdipoRon | AG-CR1-0154 | AdipoGen Life Sciences | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AdipoRon . HCl (water soluble) | AG-CR1-0156 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Compound 112254 . HCl (water soluble) | AG-CR1-0157 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||