AdipoGen Life Sciences

FNDC5:Fc (human) (rec.)

Product Code:
 
AG-40B-0153
Product Group:
 
Recombinant Proteins
Antibody Clonality:
 
Enzyme
Regulatory Status:
 
RUO
Target Species:
  • Bovine (Cattle)
  • Human
  • Mouse
Shipping:
 
Blue Ice
Storage:
 
Short term: +4°C. Long term: -20°C
 

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CodeSizePrice
AG-40B-0153-C01010 ug£206.00
Quantity:
AG-40B-0153-30103 x 10 ug£401.00
Quantity:
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Further Information

Alternate Names/Synonyms:
Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2.
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).
Molecular Weight:
~52kDa
NCBI, Uniprot Number:
Q8NAU1
Package Type:
Plastic Vial
Product Description:
Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).
Purity:
>95% (SDS-PAGE)
Sequence:
FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human.
Source / Host:
HEK 293 cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

References

FNDC5 is produced in the stomach and associated to body composition: S. Barja-Fernandez, et al.; Sci. Rep. 6, 23067 (2016)