Trypacidin
| Code | Size | Price |
|---|
| BVT-0442-M001 | 1 mg | £130.00 |
Quantity:
| BVT-0442-M005 | 5 mg | £365.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
+4°C
Storage:
-20°C
Documents
Further Information
Appearance:
White to off-white solid.
CAS:
1900-29-4
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light when in solution.
Hazards:
H319
InChi:
InChI=1S/C18H16O7/c1-9-5-12(22-2)15-13(6-9)25-18(16(15)20)11(17(21)24-4)7-10(19)8-14(18)23-3/h5-8H,1-4H3/t18-/m1/s1
InChiKey:
KMZYINVXZDQCKC-GOSISDBHSA-N
Long Description:
Chemical. CAS: 1900-29-4. Formula: C18H16O7. MW: 344.3. Isolated from Aspergillus fumigatus. Antibiotic. Antibacterial and antiprotozoal (trypanocidal). Toxic to human A549 lung cells. Necrosis inducer. Toxic to human bronchial epithelial cells. Stimulating the growth of corn seedling roots. Inhibits IL-6 secretion, collagen IV and fibronectin production
MDL:
MFCD01684067
Molecular Formula:
C18H16O7
Molecular Weight:
344.3
Package Type:
Plastic Vial
Precautions:
P280, P305, P351, P338
Product Description:
Antibiotic. Antibacterial and antiprotozoal (trypanocidal). Toxic to human A549 lung cells. Necrosis inducer. Toxic to human bronchial epithelial cells. Stimulating the growth of corn seedling roots. Inhibits IL-6 secretion, collagen IV and fibronectin production
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
COC(=O)C1=CC(=O)C=C(OC)[C@]11OC2=C(C1=O)C(OC)=CC(C)=C2
Solubility Chemicals:
Soluble in DMSO, acetone or dichloromethane.
Source / Host:
Isolated from Aspergillus fumigatus.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Antiprotozoal antibiotics. II. Isolation and characterization of trypacidin, a new antibiotic, active against Trypanosoma cruzi and Toxoplasma gondii: J. Balan, et al.; J. Antibiot. 16, 157 (1963) | Trypacidin a new protozoal antibiotic: J. Balan, et al.; Naturwissenschaften 5, 227 (1964) | The structure of Trypacidin: J. Balan, et al.; Acta Chem. Scand. 19, 528 (1965) | Growth of Trypanosoma cruzi in human heart tissue cells and effects of aminonucleoside of puromycin, trypacidin and aminopterin: W.E. Gutteridge, et al.; J. Protozool. 16, 521 (1969) | Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells: T. Gauthier, et al.; PLoS One 7, e29906 (2012) | Chemical constituents of Aspergillus sp EJC08 isolated as endophyte from Bauhinia guianensis and their antimicrobial activity: E. Pinheiro, et al.; An. Acad. Bras. Cienc. 85, 1247 (2013) | Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy: Y. Yang, et al.; Bioorg. Med. Chem. Let. 23, 3905 (2013)
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