Z-Leu-Leu-Leu-B(OH)2 [MG-262]
| Code | Size | Price |
|---|
| AG-CP3-0024-C200 | 200 ug | £75.00 |
Quantity:
| AG-CP3-0024-M001 | 1 mg | £170.00 |
Quantity:
| AG-CP3-0024-M005 | 5 mg | £570.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Blue Ice
Storage:
-20°C
Further Information
Alternate Names/Synonyms:
Z-LLL-B(OH)2; Proteasome Inhibitor III
Appearance:
Solid lyophilized powder.
CAS:
179324-22-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Avoid freeze/thaw cycles.
InChi:
InChI=1S/C25H42BN3O6/c1-16(2)12-20(24(31)29-22(26(33)34)14-18(5)6)27-23(30)21(13-17(3)4)28-25(32)35-15-19-10-8-7-9-11-19/h7-11,16-18,20-22,33-34H,12-15H2,1-6H3,(H,27,30)(H,28,32)(H,29,31)/t20-,21-,22-/m0/s1
InChiKey:
MWKOOGAFELWOCD-FKBYEOEOSA-N
Long Description:
Chemical. CAS: 179324-22-2. Formula: C25H42BN3O6. MW: 491.4. Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Similar structure as MG-132 (AG-CP3-0011) but much higher potency.
MDL:
MFCD02179373
Molecular Formula:
C25H42BN3O6
Molecular Weight:
491.4
Package Type:
Vial
Product Description:
Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Similar structure as MG-132 (AG-CP3-0011) but much higher potency.
Purity:
>95% (HPLC)
Sequence:
Z-Leu-Leu-Leu-B(OH)2
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1)B(O)O
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Down-regulation of Flt-1 gene expression by the proteasome inhibitor MG262: J. Mezquita, et al.; J. Cell. Biochem. 89, 1138 (2003) | Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate: A.F. Kisselev, et al.; J. Biol. Chem. 281, 8582 (2006) | Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease: H. Frase, et al.; Biochemistry 45, 8264 (2006) | Characterization of the Physiological Turnover of Native and Inactivated Cytochromes P450 3A in Cultured Rat Hepatocytes: A Role for the Cytosolic AAA ATPase p97?: S. Faouzi, et al.; Biochemistry 46, 7793 (2007) | Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment: P.G. Thomes, et al.; BBRC 417, 262 (2012) | Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells: N. Tange, et al.; Biomed. Pharmacother. 128,110330 (2020)
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