Cytochalasin J
| Code | Size | Price |
|---|
| BVT-0450-M001 | 1 mg | £110.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Deacetylcytochalasin H; Kodocytochalasin 2; Paspalin P II
Appearance:
White solid.
CAS:
53760-20-6
Class:
6.1
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS06
Handling Advice:
Protect from light when in solution.
Hazards:
H300, H310, H330, H361
InChi:
InChI=1S/C28H37NO4/c1-17-9-8-12-21-25(31)19(3)18(2)24-22(15-20-10-6-5-7-11-20)29-26(32)28(21,24)23(30)13-14-27(4,33)16-17/h5-8,10-14,17-18,21-25,30-31,33H,3,9,15-16H2,1-2,4H3,(H,29,32)/b12-8+,14-13-/t17-,18+,21-,22-,23+,24?,25+,27+,28+/m0/s1
InChiKey:
UKQNIEMKORIOQM-ITYZSRHZSA-N
Long Description:
Chemical. CAS: 53760-20-6. Formula: C28H37NO4. MW: 451.6. Isolated from Phomopsis sp. Mycotoxin. Phytotoxic and cytotoxic agent. Immunosuppressive activity. Affects chromosome congression and spindle microtubule organization in PtK1 cells. Actin and myosin inhibitor.
MDL:
MFCD00077708
Molecular Formula:
C28H37NO4
Molecular Weight:
451.6
Package Type:
Plastic Vial
PG:
II
Precautions:
P301, P310, P302, P350, P304, P340
Product Description:
Mycotoxin. Phytotoxic and cytotoxic agent. Immunosuppressive activity. Affects chromosome congression and spindle microtubule organization in PtK1 cells. Actin and myosin inhibitor.
Purity:
>98% (NMR)
Signal Word:
Danger
SMILES:
[H]C12[C@H](CC3=CC=CC=C3)NC(=O)[C@@]11[C@@H](C=CC[C@H](C)C[C@](C)(O)C=C[C@H]1O)[C@H](O)C(=C)[C@H]2C
Solubility Chemicals:
Soluble in DMSO or water.
Source / Host:
Isolated from Phomopsis sp.
Transportation:
Excepted Quantity
UN Nummer:
UN 3462
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.
References
Isolation and biological properties of deacetylcytochalasin H from Phomopsis sp.: R.J. Cole, et al.; J. Agric. Food Chem. 29, 205 (1981) | A new immunosuppressive cytochalasin isolated from a Pestalotia sp.: N.S. Burres, et al.; J. Antibiot. 45, 1367 (1992) | Cytochalasin J affects chromosome congression and spindle microtubule organization in PtK1 cells: J.A. Snyder, et al.; Cell Motil. Cytoskel. 32, 245 (1995) | The effect of cytochalasin J on kinetochore structure in PTK1 cells is mitotic cycle dependent: G.A. Wrench & J.A. Snyder; Cell Biol. Int. 25, 815 (2001) | Redistribution of motor proteins by cytochalasin J treatment: R.W. Robinson & J.A. Snyder; Cell Biol. Int. 27, 665 (2003) | Colocalization studies of Arp1 and p150Glued to spindle mircotubules during mitosis: the effect of cytochalasin J on the organization of microtubules and motor proteins in PtK1 cells: R.W. Robinson, et. al.; Cell Biol. Int. 30, 631 (2006) | Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa: S. Xu, et al.; Chem. Biodiv. 6, 739 (2009) | Both actin and myosin inhibitors affect spindle architecture in PtK1 cells: J.A. Snyder, et al.; Protoplasma 240, 57 (2010)