Emodin

Vasorelaxant effect of emodin, an anthraquinone from a Chinese herb: H.C. Huang, et al.; Eur. J. Pharmacol. 205, 289 (1991) | Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum: H. Jayasuriya, et al.; J. Nat. Prod. 55, 696 (1992) | Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells: A. Kumar, et al.; Oncogene 17, 913 (1998) | Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor: H. Yim, et al.; Planta Med. 65, 9 (1999) | Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity: H. Matsuda, et al.; Bioorg. Med. Chem. Lett. 11, 1839 (2001) | Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9: G. Srinivas, et al.; Eur. J. Pharmacol. 473, 117 (2003) | Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth: T.L. Cha, et al.; Cancer Res. 65, 2287 (2005) | Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation: H.J. Kwak, et al.; Int. J. Cancer 118, 2711 (2006) | Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor: A. Muto, et al.; Mol. Cancer Ther. 6, 987 (2007) | Screening of Kit inhibitors: suppression of Kit signaling and melanogenesis by emodin: S.J. Lee, et al.; Phytother. Res. 24, 308 (2010) | Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity: T. Liu, et al.; Brain Res. 1347, 149 (2010) | Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor: L. Liu, et al.; Eur. J. Pharmacol. 640, 15 (2010) | Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice: Y. Feng, et al.; Br. J. Pharmacol. 161, 113 (2010) | Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARgamma-agonist activity: Z. Chen, et al.; J. Cell Biochem. 113, 3547 (2012) | Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis: S.Z. Lin, et al.; PLoS One 7, e42146 (2012) | The distinct mechanisms of the antitumor activity of emodin in different types of cancer: W.T. Wei, et al.; Oncol. Rep. 30, 2555 (2013) (Review) | Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620: T. Pooja & D. Karunagaran; Eur. J. Pharmacol. 742, 55 (2014) | Emodin induces neurite outgrowth through PI3K/Akt/GSK-3beta-mediated signaling pathways in Neuro2a cells: S.J. Park, et al.; Neurosci. Lett. 588, 101 (2015) | Anti-Inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation: J.W. Han, et al.; Int. J. Mol. Sci. 16, 8102 (2015) | Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein: H. Min, et al.; PLoS One 12, e0187971 (2017)