Arglabin
Product Code: AG-CN2-0458
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0458-M001 | 1 mg | £70.00 |
Quantity:
| AG-CN2-0458-M005 | 5 mg | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Arglabine
Appearance:
White to off-white solid.
CAS:
84692-91-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H302
InChi:
InChI=1S/C15H18O3/c1-8-4-7-15-11(8)12-10(9(2)13(16)17-12)5-6-14(15,3)18-15/h4,10-12H,2,5-7H2,1,3H3/t10-,11+,12-,14-,15+/m0/s1
InChiKey:
UVJYAKBJSGRTHA-CUZKYEQNSA-N
Long Description:
Chemical. CAS: 84692-91-1. Formula: C15H18O3. MW: 246.3. Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora. Anticancer compound. Farnesyltransferase inhibitor. Potent anti-inflammatory agent. NF-kappaB inhibitor. Inflammasome inhibitor. Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
MDL:
MFCD11519463
Molecular Formula:
C15H18O3
Molecular Weight:
246.3
Package Type:
Vial
Precautions:
P270, P301, P312, P330
Product Description:
Anticancer compound. Farnesyltransferase inhibitor. Potent anti-inflammatory agent. NF-kappaB inhibitor. Inflammasome inhibitor. Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
Purity:
>95% (HPLC)
Signal word:
Warning
SMILES:
[H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C
Solubility Chemicals:
Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water.
Source / Host:
Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall: C. Bottex-Gauthier, et al.; Biotechnol. Ther. 4, 77 (1993) | Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase: T.E. Shaikenov, et al.; Oncol. Rep. 8, 173 (2001) | Biomimetic semisynthesis of arglabin from parthenolide: J.D. Zhai, et al.; JOC 77, 7103 (2012) | Synthesis and biological evaluation of antitumor-active arglabin derivatives: R. Csuk, et al.; Arch Pharm. 345, 215 (2012) | Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-kappaB activation and MCP-1 and TGF-beta1 expression in rat mesangial cells: Q.Q. Jia, et al.; Molecules 18, 13061 (2013) | Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin: S.H. Lone & K.A. Bhat; THL 56, 1908 (2015) | Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)
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