Celastrol

The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria: H. Sassa, et al.; BBRC 172, 890 (1990) | Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease: A.C. Allison, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341 (2001) | Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production: H.Z. Jin, et al.; J. Nat. Prod. 65, 89 (2002) | Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol: M. Nagase, et al.; Biosci. Biotechnol. Biochem. 67, 1883 (2003) | Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid: J.H. Lee, et al.; Biochem. Pharmacol. 72, 1311 (2006) | Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice: H. Yang, et al.; Cancer Res. 66, 4758 (2006) | Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation: Z. Lu, et al.; Cancer Lett. 290, 182 (2010) | Celastrol: Molecular targets of Thunder God Vine: A. Salminen, et al.; BBRC 394, 439 (2010) (Review) | Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway: H. Zhu, et al.; J. Pharmacol. Exp. Ther. 334, 489 (2010) | Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1alpha pathway: L. Huang, et al.; Int. J. Mol. Med. 27, 407 (2011) | NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action: V. Jaquet, et al.; Br. J. Pharmacol. 164, 507 (2011) | Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication: V. Narayan, et al.; J. Mol. Biol. 410, 972 (2011) | Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways: R. Kannaiyan, et al.; Apoptosis 16, 1028 (2011) | Celastrol, an NF-kappaB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice: J.E. Kim, et al.; PLoS One 8, e62068 (2013) | Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways: T. Gwag, et al.; Arch. Biochem. Biophys. 537, 21 (2013) | Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study: H.Y. Li, et al.; Cell Death Dis. 6, e1604 (2015) | Treatment of obesity with celastrol: J. Liu, et al.; Cell 161, 999 (2015)