AEBSF . hydrochloride
| Code | Size | Price |
|---|
| AG-CR1-3610-M050 | 50 mg | £45.00 |
Quantity:
| AG-CR1-3610-M250 | 250 mg | £90.00 |
Quantity:
| AG-CR1-3610-G001 | 1 g | £180.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
4-(2-Aminoethyl)benzenesulfonylfluoride; Pefabloc SC
Appearance:
White solid.
CAS:
30827-99-7
Class:
8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS05
Handling Advice:
Protect from light and moisture.
Hazards:
H314, H318
InChi:
InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChiKey:
WRDABNWSWOHGMS-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 30827-99-7. Formula: C8H10FNO2S . HCl. MW: 203.2 . 36.5. Synthetic. Water soluble, irreversible serine protease (chymotrypsin, kallikrein, plasmin, thrombin and trypsin) inhibitor. Stable, non-toxic alternative to PMSF. Potent, selective inhibitor of Site-1-protease (S1P). Used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation by selectively inhibiting S1P. NAD(P)H oxidase inhibitor. Inhibits activation of TGFbeta and activates JNK and p38 MAP kinases. beta-Secretase inhibitor. Shown to inhibit beta-amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.
MDL:
MFCD00132962
Molecular Formula:
C8H10FNO2S . HCl
Molecular Weight:
203.2 . 36.5
Package Type:
Vial
PG:
II
Precautions:
P260, P280, P301, P330, P331, P303, P361, P353, P304, P340, P305, P351, P338
Product Description:
Water soluble, irreversible serine protease (chymotrypsin, kallikrein, plasmin, thrombin and trypsin) inhibitor. Stable, non-toxic alternative to PMSF. Potent, selective inhibitor of Site-1-protease (S1P). Used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation by selectively inhibiting S1P. NAD(P)H oxidase inhibitor. Inhibits activation of TGFbeta and activates JNK and p38 MAP kinases. beta-Secretase inhibitor. Shown to inhibit beta-amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
[Cl-].[NH3+]CCC1=CC=C(C=C1)S(F)(=O)=O
Solubility Chemicals:
Soluble in water or 100% ethanol.
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
UN 3261
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the Cla component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide: B.R. Baker & M. Cory; J. Med. Chem. 14, 119 (1971) | Synthetic low molecular weight inhibitors of serum kallikrein: F. Markwardt, et al.; Biochem. Pharmacol. 23, 2247 (1974) | Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF: M. Citron, et al.; Neuron 17, 171 (1996) | Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997) | 4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999) | Irreversible inhibitors of serine, cysteine, and threonine proteases: J.C. Powers, et al.; Chem. Rev. 102, 4639 (2002) | A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6: T. Okada, et al.; J. Biol. Chem. 278, 31024 (2003) | Proteolytic activation of latent TGF-beta precedes caspase-3 activation and enhances apoptotic death of lung epithelial cells: V.T. Solovyan & J. Keski-Oja; J. Cell Physiol. 207, 445 (2006) | Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease: S. Saw, et al.; PLoS One 7, e41107 (2012) | Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro: M. Oba, et al.; BBRC 570, 21 (2021)