E-Selectin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-553-0.01mg | 0.01mg | £300.00 |
Quantity:
| PSI-40-553-0.05mg | 0.05mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized E-Selectin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted E-Selectin stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein
Documents
Further Information
Additional Names:
GTB, NAGAT, A3GALNT, A3GALT1, Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, A transferase
Background:
Selectins are a family of calcium-dependent type 1 transmembrane proteins. Endothelial (E)-selectin is a heavily glycosylated transmembrane protein expressed by activated endothelial cells in microvascular linings. E-selectin, along with P-selectin and L-selectin, initiate recruitment of circulating leukocytes from blood to sites of inflammation in the vascular lining through interaction with specific cell surface associated carbohydrate determinants. E-selectin consists of an N-terminal type 1 lectin domain, an EGF-like domain, 6 sushi (CCP/SCR) domains, a transmembrane sequence, and a short cytoplasmic domain. Recombinant human E-selectin is a 58.6 kDa protein containing 535 amino acid residues, corresponding to the extracellular portion of the full length protein. Due to glycosylation, E-selectin migrates at an apparent molecular weight of approximately 65-85 kDa by SDS-PAGE analysis under reducing conditions.
Biological Activity:
Biological activity was measured by its ability to support adhesion of U937 cells, a human hystiocytic lymphoma cell line. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
28
NCBI Official Name:
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
NCBI Official Symbol:
ABO
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_065202.2
Protein GI Number:
58331216
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
CHO cells
Swissprot #:
P16442