Soluble RANK Ligand Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-296-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-296-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Soluble RANK Ligand recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble RANK Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C
Documents
Further Information
Additional Names:
ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, ODF
Background:
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na?ve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant human sRANKL is a 20.0 kDa polypeptide comprising the TNF homologous region of RANKL (176 amino acid residues).
Biological Activity:
Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells. The expected ED50 for this effect is 10.0-25.0 ng/ml.
NCBI Gene ID #:
8600
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 11
NCBI Official Symbol:
TNFSF11
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003692.1
Protein GI Number:
4507595
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O14788