GDF-11 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-209-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-209-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized GDF-11 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted GDF-11 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
Documents
Further Information
Additional Names:
BMP11, BMP-11, BMP11, Bone morphogenetic protein 11, GDF-11
Background:
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.
Biological Activity:
The ED50 was determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 cells. The ED50 for this effect is 8-10 ng/ml.
NCBI Gene ID #:
10220
NCBI Official Name:
growth differentiation factor 11
NCBI Official Symbol:
GDF11
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_005802.1
Protein GI Number:
5031613
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O95390