Soluble TNF Receptor Type I Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-299-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-299-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Soluble TNF Receptor Type I recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble TNF Receptor Type I is stable for at least 3 months when stored in working aliquots with a carrier prot
Documents
Further Information
Additional Names:
FPF, MS5, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55, TNFR1-d2, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1
Background:
TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFκB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. Recombinant human sTNFR1 is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein.
Biological Activity:
Biological activity was determined by its inhibitory effect of the TNF - a mediated cytotoxicity in murine L - 929 cells. The ED50 for this effect in the presence of 0.25 ng/mL of recombinant human TNF - a, is 0.05 μg/mL.
NCBI Gene ID #:
7132
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 1A
NCBI Official Symbol:
TNFRSF1A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001056.1
Protein GI Number:
4507575
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P19438