BMP-3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-547-0.01mg | 0.01mg | £300.00 |
Quantity:
| PSI-40-547-0.05mg | 0.05mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized BMP-3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted BMP-3 stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing
Documents
Further Information
Additional Names:
BMP-3A, BMP3A, Bone morphogenetic protein 3, Bone morphogenetic protein 3A, BMP-3
Background:
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-3 is abundantly found in adult bone, and to a lesser extent fetal cartilage. BMP-3 inhibits osteogenesis and bone formation by activating a signaling cascade that antagonizes the signaling of pro-osteogenic BMPs. Recombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.
Biological Activity:
Biological activity was determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
651
NCBI Official Name:
bone morphogenetic protein 3
NCBI Official Symbol:
BMP3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001192.2
Protein GI Number:
126507087
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P12645