Thrombomodulin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-532-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-532-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Thrombomodulin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Thrombomodulin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with
Documents
Further Information
Additional Names:
TM, THRM, AHUS6, BDCA3, CD141, THPH12, Thrombomodulin, Fetomodulin, TM
Background:
Thrombomodulin (TM, CD141, THBD) is an endothelial cell expressed transmembrane glycoprotein that can form a complex with the coagulation factor, Thrombin. The Thrombomodulin/Thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin and thereby effectively prevents continued coagulation. Reduced levels of Thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of Thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory related diseases. Recombinant soluble Thrombomodulin is a 491 amino acid glycoprotein containing the extracellular domain of Thrombomodulin.
Biological Activity:
Biological activity was measured by its ability to activate protein C induced cleavage of the chromogenic substrate, BOC-Asp-Pro Arg-AMC in the presence of thrombin. The specific activity is greater than 500 pmoles/min/μg.
NCBI Gene ID #:
7056
NCBI Official Name:
thrombomodulin
NCBI Official Symbol:
THBD
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000352.1
Protein GI Number:
4507483
Purity:
Greater than or equal to 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P07204