Thrombopoeitin Recombinant Protein

ProSci
Product Code: PSI-40-537
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-40-537-0.01mg0.01mg£481.00
Quantity:
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Overview

Regulatory Status: RUO
Target Species: Rat
Storage:
The lyophilized Thrombopoeitin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Thrombopoeitin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with

Documents

Further Information

Additional Names:
Thrombopoietin
Background:
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 0.2 ng/mL, corresponding to a specific activity of ≥ 5 x 107 units/mg.
NCBI Gene ID #:
81811
NCBI Official Name:
thrombopoietin
NCBI Official Symbol:
Thpo
NCBI Organism:
Rattus norvegicus
Physical State:
Lyophilized
Protein Accession #:
NP_112395.1
Protein GI Number:
13592113
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P49745