FGFR 4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-317-0.2mg | 0.2mg | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
FGFR4, CD334, JTK2, MGC20292, TKF
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.
Background References:
- Eswarakumar VP, et al., 2005, Cytokine Growth Factor Rev. Apr;16(2):139-49.
- Wang J, et al., 2004, Clin Cancer Res. Sep 15;10(18 Pt 1):6169-78.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized FGFR4 /CD334 Protein at 5 μg/mL (100 μl/well) can bind Biotinylated Human bFGF Protein . The EC50 is typically 0. 96 μg/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2264
NCBI Official Name:
fibroblast growth factor receptor 4
NCBI Official Symbol:
FGFR4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
40 kDa
Protein Accession #:
AAH11847
Purity:
>98% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P22455