FOLR2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-326-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, FBP
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
Background References:
- Ratnam, M. et al., 1989, Biochemistry, 28(20):8249-54.
- Ross, J.F. et al., 1999, Cancer, 85:348.
- Reddy, J.A. et al., 1999, Blood, 93:3940.
- Ross, J.F. et al.,1994, Cancer 73:2432.
Biological Activity:
Measured by its binding ability in a functional ELISA. When Folic AcidBovine Serum Albumin was coated at 5μg/ml (100μl/well), the concentration of rhFOLR2 that produces 50% of the optimal binding response was found to be approximately 0. 15-1. 1 nM.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2350
NCBI Official Name:
folate receptor 2 (fetal)
NCBI Official Symbol:
FOLR2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
26 kDa
Protein Accession #:
P14207-1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P14207