CD5 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-118-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD5, LEU1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.
Background References:
- van de Velde H., et al., 1991, Nature 351:662-665.
- Brill L.M., et al., 2004, Anal. Chem. 76:2763-2772.
- Rodamilans B., et al., 2007, J. Biol. Chem. 282:12669-12677.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
921
NCBI Official Name:
CD5 molecule
NCBI Official Symbol:
CD5
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
40.5 kDa
Protein Accession #:
NP_055022
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P06127