DKK 3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-239-0.2mg | 0.2mg | £838.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
DKK3, REIC, RIG
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
Background References:
- Medinger M, Tzankov A,et al., 2011, Thromb Haemost. 105:72-80.
- Yue W, Sun Q, et al., 2008, Carcinogenesis. 29(1):84-92..
- Pinho S, Niehrs C.et al., 2007, Differentiation. 75(10):957-67.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
27122
NCBI Official Name:
dickkopf WNT signaling pathway inhibitor 3
NCBI Official Symbol:
DKK3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
37.6 kDa
Protein Accession #:
NP_001018067.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9UBP4